- Sartorial Magazine
- Secular Student Alliance (SSA)
- Sigma Alpha
- Sigma Chi Fraternity
- Sigma Delta Pi
- Sigma Gamma Rho Sorority Inc. (SGRho)
- Sigma Kappa
- Sigma Lambda Chi (SLX)
- Sigma Lambda Gamma National Sorority, Inc. (SLG)
- Sigma Nu Fraternity
- Sigma Phi Epsilon (Sig Ep)
- Sigma Pi Fraternity
- Sigma Sigma Sigma (Tri Sigma)
- Sigma Tau Delta (STD)
- Sign Language Club (SLC)
- Sister Circle
- Social Work Club (SWK Club)
- Society for Human Resource Management (SHRM)
- Society of Physics Students (SPS)
- Society of Science Educators (SoSE)
- Sound Bearrier (SB)
- South Asian Students Association
- Southwest Missouri Student Math Teacher Organization ((SM)^2TO)
- Springfield Design Association (SDA)
- Student Academy of Audiology (SAA)
- Student Activities Council (SAC)
- Student Affairs Graduate Association (SAGA)
- Student Alumni Association (S.A.A.)
- Student Dietetic Association (SDA )
- Student Government Association (SGA)
- Student Mobilization (StuMo)
- Student National Education Association (SNEA)
- Student Nursing Organization (SNO)
- Student Speech and Theatre Association of Missouri at Missouri State University (Student S.T.A.M.)
- Student-Athlete Advisory Committee (SAAC)
- Students for a Sustainable Future
- Students in Design (SiD)
Student Organizations